TKS5-positive invadopodia-like structures in human tumor surgical specimens
نویسندگان
چکیده
منابع مشابه
The SRC substrate Tks5, podosomes (invadopodia), and cancer cell invasion.
Some years ago, we employed a screen of phage cDNA expression libraries to identify novel substrates of the protein tyrosine kinase Src. One of these, Tks5 (previously known as Fish), is a large scaffolding protein with an amino-terminal PX domain and five SH3 domains. In normal fibroblasts, Tks5 is cytoplasmic, but the protein is found in podosomes when the cells are transformed with Src. Usin...
متن کاملThe Invadopodia Scaffold Protein Tks5 Is Required for the Growth of Human Breast Cancer Cells In Vitro and In Vivo
The ability of cancer cells to invade underlies metastatic progression. One mechanism by which cancer cells can become invasive is through the formation of structures called invadopodia, which are dynamic, actin-rich membrane protrusions that are sites of focal extracellular matrix degradation. While there is a growing consensus that invadopodia are instrumental in tumor metastasis, less is kno...
متن کاملHuman cytomegalovirus infection in tumor specimens of Iranian patients with glioma
Human cytomegalovirus (HCMV) causes persistent infection in humans and severe diseases in fetus andimmunocompromised individuals. Although HCMV is not currently implicated in human cancer, emerging evidence suggests that HCMV infection might be specifically associated with some human malignancies including glioma. Glioma is one of the most common brain tumors affecting children and adults. In t...
متن کاملTks5-dependent formation of circumferential podosomes/invadopodia mediates cell–cell fusion
Osteoclasts fuse to form multinucleated cells during osteoclastogenesis. This process is mediated by dynamic rearrangement of the plasma membrane and cytoskeleton, and it requires numerous factors, many of which have been identified. The underlying mechanism remains obscure, however. In this paper, we show that Tks5, a master regulator of invadopodia in cancer cells, is crucial for osteoclast f...
متن کاملSV40 detection in human tumor specimens.
Cristaudo et al. (1) provided the first molecular epidemiologic evidence supporting cocarcinogenesis between asbestos and SV40 in human malignant mesothelioma. The authors have also proposed that an inadequate technical procedure to detect SV40 could produce false-positive or false-negative results. Here we provide information for the optimization of the experimental procedure and to prevent la...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Experimental and Molecular Pathology
سال: 2019
ISSN: 0014-4800
DOI: 10.1016/j.yexmp.2018.11.005